Research Associate, Analytical and Formulations Development

Ambrx, Inc. is a biopharmaceutical company with a mission to deliver breakthrough protein therapeutics. Ambrx is based on a fundamental advance in protein biosynthesis that enables the company to genetically engineer proteins with new amino acid building blocks beyond the common twenty, enabling the biosynthesis of proteins with new physical, chemical and pharmacological properties. At Ambrx, we are dedicated to assembling and developing an exceptional team and a breakthrough technology to create the next generation of protein-based medicines.
Major Responsibilities:
‚ ĘTake ownership of analytical method development for complex protein biomolecules (including E. coli, yeast, CHO derived proteins/antibodies and ADC) and related impurities conducting the preliminary qualification of these test methods for protein therapeutic candidates in pre-clinical and early-phase clinical development.
‚ ĘCharacterize proteins and impurities utilizing conventional and specialty analytical techniques to understand degradation pathways and improve protein stability
‚ ĘWrite standard test methods, qualification protocols and reports.
‚ ĘSummarize, interpret, and critically evaluate analytical data. Present results at Group/Team meetings.
‚ ĘProvide analytical support for upstream, downstream and conjugation process development activities.
‚ ĘPresent analytical/stability data to cross functional project teams, coordinate resources within the analytical group to meet project goals and timelines.
‚ ĘProactively identify potential problems or opportunities in the context of project teams to facilitate advancement of product candidates.‚ ĘB.S in biophysics, biochemistry or related field with 4+ yrs industrial experience in protein analytical development or MS degree with +1 yrs experience. The job title and compensation will be determined based on experience and knowledge of a candidate.
‚ ĘKnowledge and hands-on experience with a wide range of physicochemical characterization techniques (including but not limited to): HPLC (SEC, RP,ICX), mass spectrometry (intact mass, peptide mapping), CE-SDS, CE-SDS, DSC, SEC-MALS
‚ ĘKnowledge and experience in developing and applying new technologies for complex protein molecules, excellent troubleshooting skills are required.
‚ ĘExperience with formulation development is a plus.
‚ ĘExcellent oral, written and interpersonal communication skills and an ability to work across scientific disciplines.
To be considered as an applicant, please submit your resume/CV referencing the specific position of interest and position code (05-17BA). Applicants whose qualifications and experience most closely match the requirements of the position will be reviewed. Candidates will only be contacted for evaluative discussions. Ambrx offers competitive compensation & benefits. EOE

Don't Be Fooled

The fraudster will send a check to the victim who has accepted a job. The check can be for multiple reasons such as signing bonus, supplies, etc. The victim will be instructed to deposit the check and use the money for any of these reasons and then instructed to send the remaining funds to the fraudster. The check will bounce and the victim is left responsible.

More Jobs

Research Associate, Analytical Development (Co...
San Francisco, CA Audentes Therapeutics, Inc.
Research Associate, Analytical Development
South San Francisco, CA Ascent
Research Associate, Analytical Development
Menlo Park, CA Orchard Therapeutics
Senior Research Associate, Analytical Development
Menlo Park, CA Orchard Therapeutics
Research Associate/Senior Research Associate, ...
San Francisco, CA California Life Company