Scientist, Mammalian Cell Culture, Process Development

About Ambrx:
Ambrx, Inc. is a biopharmaceutical company with a mission to deliver breakthrough protein therapeutics using an expanded genetic code. Unlike conventional conjugation techniques that create a mixture of suboptimal molecules, Ambrx technology combines site specific conjugation with proprietary linkers, payloads and pharmacokinetic extenders to create a single molecular species that is optimized for safety, efficacy and biophysical properties. We call this process Protein Medicinal Chemistryâ ¢
Ambrx is seeking a highly-motivated Scientist I/II to be a key member of a fast-paced and dynamic organization.
â ¢Responsible for developing cell culture medium, feeding strategies, process parameter optimization, and scale-up to support R&D, large scale production, pre-clinical, and clinical activities.
â ¢Participates in writing development reports, protocols, batch records and technology transfer.
â ¢Must demonstrate strong scientific/technical and interpersonal skills as well as the ability to communicate effectively.
â ¢Applies biological and engineering expertise to develop recombinant protein production processes suitable for large-scale cGMP manufacturing and acts as a mentor for those with similar or less engineering expertise, providing both technical expertise and leadership to understand potential career paths.
â ¢This job may require some travel to development partners and other manufacturing sites both in and outside the US.â ¢PhD with a minimum of 1+ year(s) or Master's Degree with a minimum 8+ years industrial experience and a degree in Chemical Engineering or related field.
â ¢Must have hands on experience in process development utilizing CHO cells to produce biologics using spin tubes, shake flasks, and bioreactors
â ¢Knowledgeable in cell culture process scale-up and technology transfer to contract manufacturing organizations.
â ¢Must have a proven record of innovation
â ¢Must have the ability to apply scientific and engineering principles to solve complex problems.
â ¢Must have a good understanding of cell physiology, metabolism, and cell biology
â ¢Must have the ability to multitask and adapt in a fast paced environment and stay focused on project deliverables.
â ¢Work with minimum supervision in designing and executing experiments and analyzing data.
Additional Desired Experience and Skills:
â ¢Knowledge of Design of Experiments (DOE) and statistical analysis of data.
â ¢Working knowledge of GMPs and experience writing SOPs and batch records.
â ¢Medium development experience for CHO cell culture
â ¢Experience with pilot scale bioreactors and primary recovery equipment.
To be considered as an applicant, please submit your resume/CV referencing the specific position of interest and position code to . Applicants whose qualifications and experience most closely match the requirements of the position will be reviewed. Candidates will only be contacted for evaluative discussions. Ambrx offers competitive compensation & benefits. EOE

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